Knee osteoarthritis · Clinical expertise
Extensive clinical experience. Published research. A considered approach to your knee.
An early UK adopter, Professor Lee brings years of Arthrosamid experience to the decisions that matter: who may benefit, how treatment is delivered and how patients are cared for afterwards.
Arthrosamid injections
Clinic-reported experience · August 2026Patients in the published cohort
314 knees · distinct from clinic treatment volumePublished study follow-up
Patient-reported pain and knee functionClinical experience
The injection is one part of the decision. Understanding the knee, choosing the right patient and planning safe care are just as important.
Professor Lee has been involved in Arthrosamid’s early use in the UK and its development in clinical practice over five years. His clinic reported more than 1,200 injections by August 2026. That experience informs his assessment, ultrasound-guided technique and follow-up.
He has also contributed to published research, examining patient outcomes and the factors that may influence response. Clinical experience and research serve different purposes: together, they help make the discussion more specific to your knee.
For suitability, prices and the patient treatment pathway, explore Arthrosamid treatment at London Cartilage Clinic.
Explore Professor Lee’s publications02 / Published research
Professor Lee’s work includes evidence review and clinical follow-up, with the original publications available for you to read.
Professor Lee co-authored a study of 269 patients, covering 314 knees. Pain and knee-function scores improved over two years, but there was no control group. These are group findings, not a prediction of an individual result.
Journal of Clinical Orthopaedics and Trauma · Gao and colleagues, including Paul YF Lee
Read the full study2022 / Systematic review
A review co-authored by Professor Lee assessed published outcomes and adverse events across 463 patients. It helped describe the evidence available as Arthrosamid entered UK practice.
Read the reviewWhat this means for you
Ask how closely the published patients resemble you, what improvement would matter to you and what the alternatives offer.
The 2025 paper reports no study funding and no declared competing interests. Clinic experience figures are separate from the published study population.
03 / His clinical protocol
Arthrosamid remains in the joint. Professor Lee’s approach gives infection prevention particular attention, from the first assessment to the advice you take home.
Intravenous antibiotics are part of his clinic protocol and are documented in the published 2025 study.
Read the clinic’s safety informationConfirm the diagnosis, review imaging and discuss medical history, medicines, allergies and any recent infection before deciding whether to proceed.
Professor Lee developed a cautious clinic protocol that includes intravenous antibiotics before injection. The clinical team checks the antibiotic and its timing for each patient.
Sterile skin preparation and aseptic technique accompany image-guided delivery, with local anaesthetic as part of the treatment plan.
Written advice, a contact route and planned follow-up help patients understand recovery and know when a change in symptoms needs attention.
Understanding the treatment
A treatment for symptoms of knee osteoarthritis, considered as part of a wider plan.
Arthrosamid is a non-absorbable hydrogel that integrates into the synovial tissue lining the knee joint. It is intended to help with osteoarthritis symptoms. It does not regenerate cartilage.
Your symptoms, examination, scans, health and previous treatment all matter. Active infection and some other conditions can rule out treatment or mean it should be postponed.
Rehabilitation, other injections and surgery may each have a place. Professor Lee’s role is to help you weigh the options against your diagnosis and goals.
Your questions
Arthrosamid is a non-absorbable polyacrylamide hydrogel used to treat symptoms of knee osteoarthritis in adults. It integrates into the synovial tissue lining the joint. It does not regrow cartilage or cure arthritis, and it is not suitable for every painful knee.
Professor Lee was an early UK adopter of Arthrosamid. London Cartilage Clinic reported more than 1,200 injections by August 2026. He has co-authored Arthrosamid research and developed the clinic’s approach to assessment, image-guided treatment and infection precautions.
Professor Lee’s clinic protocol uses intravenous antibiotics before Arthrosamid injection as part of its infection precautions. The medicine, timing and suitability are checked by the clinical team, including allergies and previous reactions. This is combined with sterile technique and aftercare; it cannot remove all infection risk.
Some people seek Arthrosamid to help manage symptoms while considering their options. It does not correct every cause of knee pain or restore a worn-out joint. Assessment should include discussion of rehabilitation, other treatments and surgery where appropriate, rather than a promise to avoid replacement.
The London Cartilage Clinic Arthrosamid hub brings together current treatment prices, suitability information, recovery advice and booking options. Follow the treatment link below to continue with the clinic team.
London Cartilage Clinic · 66 Harley Street
Explore suitability, current prices, recovery advice and booking options in the London Cartilage Clinic Arthrosamid hub.
Sources & context
Professor Lee founded London Cartilage Clinic. The experience figure is clinic-reported and dated August 2026. The 2025 study’s disclosures relate to that paper; the existing clinical record also reports manufacturer support for a separate 2022 study at MSK Doctors. Arthrosamid is a registered trademark of Contura. This page supports a discussion with your clinician and does not replace individual advice.